Immune signalling
LL-37
What is it?
LL-37 is a 37-amino-acid peptide associated with the human cathelicidin host-defence system. It is studied for membrane interactions and immune signalling. It is not simply an antibiotic replacement: its biological effects depend on the tissue and experimental context.
How it is studied
Its amphipathic structure permits interaction with lipid membranes. Studies also examine signalling through cellular pathways involved in migration and barrier function. The same membrane activity that is useful in an antimicrobial model can affect host cells.
What the evidence shows
Original research has characterised LL-37 organisation in phospholipid membranes and investigated keratinocyte migration through epidermal growth factor receptor-associated signalling. These studies explain mechanisms in defined systems, not clinical treatment of infections or wound disease.
Limitations & safety context
Host-cell toxicity and inflammatory effects are important reasons to avoid assuming that “naturally occurring” means safe. Laboratory antimicrobial activity does not establish an effective human medicine. Sequence, counterion and impurity profiles are relevant to experimental interpretation.
Listed specifications
| Reference | Listed contents |
|---|---|
| LL375 | 5 mg |
| LL3710 | 10 mg |
Source-document quantities, not doses or a confirmation of stock. Identity, purity, component composition and suitability require separate documentation.
Research information only. No dosing, administration or treatment advice.